Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics

Data concerning cytogenetic features of childhood ependymoma are rare. In t his article, a gain of 1q was identified as the sole alteration in a primar y childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluores cence in situ hybridization (M-FISH) in addition to CGH and G-banding analy sis. In accordance with the primary tumor, a gain of Iq corresponding to an isochromosome Iq was observed indicating an early event in the tumor devel opment. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma. (C) 2001 Elsevier Sci ence Inc. All rights reserved.