S. Benezet et al., HOW TO PREDICT CARBOPLATIN CLEARANCE FROM STANDARD MORPHOLOGICAL AND BIOLOGICAL CHARACTERISTICS IN OBESE PATIENTS, Annals of oncology, 8(6), 1997, pp. 607-609
Background. We previously proposed a formula to predict carboplatin cl
earance (CL) from four patient characteristics: plasma creatinine leve
l, body weight: age, and sex (J Natl Cancer Inst 1995; 87: 573). Its a
ccuracy was studied in a subpopulation of obese patients. Patients and
methods. Twenty-five patients (16 male and 9 female, 23 to 82 years o
ld) were studied. They were 20% to 67% (median 36%) over the ideal wei
ght which was calculated according to the Lorentz equation. Their actu
al CL was obtained individually by the Siphar program. The pharmacokin
etic population program NONMEM was used to determine the best value of
substitution for weight in the formula. Results. By using the actual
weight, CL was significantly overpredicted (by more than 20% for 7 of
25 patients). By using the mean value between the ideal and the actual
weight, a good prediction of CL was obtained: the percentage of error
ranged from -21% to +22%. Conclusion: The formula is applicable to ob
ese patients if both ideal and actual weights are taken into account.