Mb. Feinstein et al., Fiberoptic bronchoscopy in allogeneic bone marrow transplantation - Findings in the era of serum cytomegalovirus antigen surveillance, CHEST, 120(4), 2001, pp. 1094-1100
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Study objectives: Pulmonary complications occur in half of allogeneic bone
marrow transplantation (BMT) patients. The incidence of these complications
has been reduced by prophylaxis against Pneumocystis carinii pneumonia, pr
eemptive therapy in patients at high risk for cytomegalovirus (CMV) reactiv
ation, and, more recently, screening for serum CMV antigen. Since fiberopti
c bronchoscopy (FOB) has historically been the primary diagnostic test to e
valuate BMT patients with pulmonary disease, a review was performed to dete
rmine the impact, if any, that current prophylaxis and screening policies m
ay have had on FOB utility.
Design: The records of 174 adult patients undergoing BMT between January 19
97 and December 1999 were reviewed to determine the diagnostic yield of FOB
and the frequency by which FOB altered management.
Results: Sixty-one patients underwent 76 bronchoscopies. FOB was diagnostic
in 32 patients (42.1% of cases) and directly changed management in 24 pati
ents (31.6% of cases). Half of these changes included the withdrawal of an
antimicrobial agent. The most common findings were infection (32 cases) and
diffuse alveolar hemorrhage (6 cases). CMV was the most prevalent infectio
n identified, but FOB resulted in the addition of antiviral therapy to only
two patients. P carinii pneumonia was not diagnosed in any patient studied
.
Conclusions: These data suggest a changing spectrum of pulmonary disease in
BMT patients. FOB has limited impact on the diagnoses of CMV disease or P
carinii pneumonia with current prophylaxis and screening strategies. It may
be useful in identifying other infectious etiologies and in eliminating un
necessary antimicrobials.