Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: A case report

Authors
Monini, P Sirianni, MC Franco, M Vincenzi, L Topino, S Goletti, D Leone, P Leone, P Chiozzini, C Nicastri, E Andreoni, M Borduagni, O Sgadari, C Rezza, G Sturzl, M Ensoli, B
Citation
P. Monini et al., Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: A case report, CLIN INF D, 33(10), 2001, pp. 1782-1785
Citations number
10
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
33
Issue
10
Year of publication
2001
Pages
1782 - 1785
Database
ISI
SICI code
1058-4838(20011115)33:10<1782:COHH8F>2.0.ZU;2-D
Abstract
A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 ( HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-alpha treatment that was accompanied by increased CD3() and CD4(+) T cell numbers and complete clearance of HHV-8 from the circul ation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the i n vitro inhibitory effects of interferon-alpha on HHV-8 infection.