IMMUNOGLOBULIN CONCENTRATIONS IN NASAL LAVAGE FLUIDS IN DOGS WITH NONSPECIFIC RHINITIS

The pathophysiology of non-specific chronic rhinitis (NSCR) in dogs is still unknown, In this study the possible role of immunological mecha nisms in NSCR is examined, by comparing immunoglobulin concentrations in nasal lavage fluids of dogs with NSCR with those of healthy dogs, T he immunoglobulin IgA was detected in nasal lavage fluids of both grou ps of dogs and the differences in relative levels of IgA in dogs with NSCR were not significant, IgM, IgG(a,b), and IgG(d) were detected mor e frequently in dogs with NSCR (P<0,05), and the relative levels were higher, The presence of IgG(a,b) may indicate the chronic character of rhinitis, and the presence;of IgG(d) the possibility of an allergic c omponent in its pathophysiology, The role of IgM is not completely cle ar.