A. Sanchez-diaz et al., HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex, CURR GENET, 40(2), 2001, pp. 110-118
The mammalian HBP2 gene has been isolated by functional complementation of
cells unable to undergo DNA replication in fission yeast. HBP2 is a protein
with a high mobility group (HMG) domain that belongs to the Sox (Sry-relat
ed HMG box) family of transcription factors. As in other members of the fam
ily, the HMG box in HBP2 is a DNA-binding domain that is essential for its
function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast
activates Cdc10-dependent transcription at G1/S and allows growth of cdc10-
129, res1 Delta and rep2 Delta mutant cells at the restrictive temperature.
The mammalian HBP2 activates transcription at G1/S in the fission yeast Sc
h. pombe.