The exponentially growing collection of genomic sequence information, the h
igh-throughput analysis of expression products, and the ability to order th
is information using advanced bioinformatics are expected to affect biotech
nology and life sciences in a profound and unprecedented way. These develop
ments offer many possibilities to improve the functionality of fermentation
s by food-grade microorganisms and to increase the microbial safety of food
s. It will be necessary to combine functional studies with comparative geno
mics approaches to provide effective strategies for improving the functiona
lity and safety of foods.