Eccrine syringofibroadenoma (ESFA) is a rare eccrine tumor. We report the c
ase of a 70-year-old woman who had presented a pincer nail deformity on the
toes for 55 years and a left painless subungual tumor for 2 years. Histolo
gic examination revealed branching anastomosing strands of epithelial cells
with ductal structures in a fibrovascular stroma. The luminal cells showed
positive staining for carcinoembryonic antigen, as in acrosyringeal cells
and cells of dermal ducts. To our knowledge, our case is the first with a s
ubungual location. In the context of chronic trauma due to a pincer nail, i
t may be classified in the reactive subtype recently described. Copyright (
C) 2001 S. Karger AG, Basel.