Although chronic obstructive pulmonary disease (COPD) is an increasingly im
portant cause of morbidity and mortality in the US, it has been neglected b
y both the provider and disease management communities partly because of th
e difficulty in demonstrating financial returns on investment and an absenc
e of evidence-based guidelines and economic evaluations of alternative ther
apeutic approaches. It is. however, a clinical entity that is amenable to s
tructured disease management with achievable and measurable clinical, finan
cial and health-related quality-of-life outcomes. Program design considerat
ions, population identification and behavior modification approaches are di
scussed. With limited objective clinical improvement potential in COPD, ris
k stratification and outcome measurement based on symptom improvement are p
roposed.