CPI-1189 - Treatment of AIDS dementia antiparkinsonian treatment of Alzheimer's dementia

Authors
Sorbera, LA Leeson, PA Castaner, J
Citation
La. Sorbera et al., CPI-1189 - Treatment of AIDS dementia antiparkinsonian treatment of Alzheimer's dementia, DRUG FUTURE, 26(7), 2001, pp. 647-650
Citations number
30
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUGS OF THE FUTURE
ISSN journal
03778282 → ACNP
Volume
26
Issue
7
Year of publication
2001
Pages
647 - 650
Database
ISI
SICI code
0377-8282(200107)26:7<647:C-TOAD>2.0.ZU;2-6
Abstract
Reaction of 4-nitrobenzoyl chloride (I) with tert-buty-lamine (II) in ethyl acetate gives the corresponding amide (III), which is reduced with H-2 ove r Pd/C in ethanol to yield 4-amino-N-tert-butylbenzamide (IV). Finally, thi s compound is acylated with acetyl chloride and TEA in ethyl acetate (1-3). Scheme 1.