Torsades de pointes caused by Mibefradil

We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to thi s drug. Multiple episodes of Torsades de pointes were documented in a 76-ye ar-old woman with significant QTc prolongation of 0.53 s. After discontinua tion of Mibefradil QTc intervals normalized and no further ventricular tach yarrythmias were observed. We conclude that Mibefradil can cause QTc prolon gation and life threatening ventricular dysrhythmias. (C) 2001 European Soc iety of Cardiology. All rights reserved.