Anticancer and antiviral properties of macrocyclic pyridinophanes and their derivatives

The permanent search for new anticancer and antiviral substances is a high- priority task. Macrocyclic pyridinophanes (MCPs) attract much attention as promising compounds with high potential of pharmaco-biological properties. The results of the experimental study of anticancer and antiviral propertie s of newly synthesized MCP, their analogues and derivatives have been prese nted. Several compounds under study have been shown to possess strong antic ancer (against human cancer cell lines) and antiviral (inhibition of adenov irus type 5 and influenza virus A/Hong Kong/1/ 68 reproduction) activity in vitro. Several MCP studied were shown to share anticancer and antiviral pr operties. The results obtained in experiment will be used for molecular top ological QSAR model evaluation.