Different production of TGF beta 1 by cisplatin-sensitive and resistant L1210 cells treated with anticancer drugs and lectins

Authors
Yakymovych, MY Yakymovych, IA Chekhun, VF Stoika, RS
Citation
My. Yakymovych et al., Different production of TGF beta 1 by cisplatin-sensitive and resistant L1210 cells treated with anticancer drugs and lectins, EXP ONCOL, 23(3), 2001, pp. 204-208
Citations number
23
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
23
Issue
3
Year of publication
2001
Pages
204 - 208
Database
ISI
SICI code
0204-3564(200109)23:3<204:DPOTB1>2.0.ZU;2-7
Abstract
Cisplatin, methotrexate, vincristin, and cytotoxic lectins (Viscum album ag glutinin 1 and Ricinus communis agglutinin) were shown to induce TGF beta1 production in L1210 murine leukemia cells. Different patterns of TGF beta1 production were observed under the effect of the above mentioned cytotoxic agents in cisplatin-sensitive and resistant L1210 cells. As TGF beta1 inhib its proliferation and induces apoptosis in cisplatin-sensitive L120 cells, it was suggested that this cytokine can mediate effects of cytotoxic agents .