The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p

Pho85p is a yeast cyclin-dependent protein kinase (Cdk) that can interact w ith 10 cyclins (Pcls) to form multiple protein kinases. The functions of mo st of the Pets, including Pc16p and Pc17p, are poorly defined. We report he re that Pc16p and Pc17p are involved in the metabolism of the branched stor age polysaccharide glycogen under certain conditions and deletion of PCL6 a nd PCL7 restores glycogen accumulation to a snf1 pcl8 pcl10 triple mutant, paradoxically activating both glycogen synthase and phosphorylase. Pho85p t hus affects glycogen accumulation through multiple Cdks composed of differe nt cyclin partners. (C) 2001 Published by Elsevier Science B.V. on behalf o f the Federation of European Biochemical Societies.