Structural and functional features of eukaryotic mRNA untranslated regions

Authors
Pesole, G Mignone, F Gissi, C Grillo, G Licciulli, F Liuni, S
Citation
G. Pesole et al., Structural and functional features of eukaryotic mRNA untranslated regions, GENE, 276(1-2), 2001, pp. 73-81
Citations number
26
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENE
ISSN journal
03781119 → ACNP
Volume
276
Issue
1-2
Year of publication
2001
Pages
73 - 81
Database
ISI
SICI code
0378-1119(20011003)276:1-2<73:SAFFOE>2.0.ZU;2-2
Abstract
The crucial role of the non-coding portion of genomes is now widely acknowl edged. In particular, mRNA untranslated regions are involved in many post-t ranscriptional regulatory pathways that control mRNA localization, stabilit y and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and prov ide some examples of bioinformatic analyses for their functional characteri zation. (C) 2001 Published by Elsevier Science B.V.