Origin and spread of HbG-San Jose in Southern Italy

Authors
Lacerra, G De Angioletti, M Pagano, L Magnano, C Medulla, E Carestia, C
Citation
G. Lacerra et al., Origin and spread of HbG-San Jose in Southern Italy, HAEMATOLOG, 86(10), 2001, pp. 1097-1098
Citations number
10
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
86
Issue
10
Year of publication
2001
Pages
1097 - 1098
Database
ISI
SICI code
0390-6078(200110)86:10<1097:OASOHJ>2.0.ZU;2-T
Abstract
We found that the HbG-San Jose mutation was associated with haplotype VII [ ---- / - +] in four families from Campania and in one family from Calabria, and with the haplotype IV [+ - + + / - +] in two families from Eastern Sic ily. These results support the hypothesis that the mutation had a unique or igin in Southern Italy and a subsequent recombination event gave rise to th e background heterogeneity.