Thrombophilia in thalassemia major patients: analysis of genetic predisposing factors

Authors
Iolascon, A Giordano, P Storelli, S Li, HH Coppola, B Piga, A Fantola, E Forni, G Cianciulli, P Perrotta, S Magnano, C Maggio, A Mangiagli, A Devoto, M
Citation
A. Iolascon et al., Thrombophilia in thalassemia major patients: analysis of genetic predisposing factors, HAEMATOLOG, 86(10), 2001, pp. 1112-1113
Citations number
12
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
86
Issue
10
Year of publication
2001
Pages
1112 - 1113
Database
ISI
SICI code
0390-6078(200110)86:10<1112:TITMPA>2.0.ZU;2-F
Abstract
Thromboembolic phenomenona have been described in patients with thalassemia major. In a multicenter, retrospective study we investigated the effect of factor V (FV Leiden), prothrombin (FII), methylene-tetrahydrofol ate reduc tase (MTHFR), PIA2 glycoprotein IIIa (GpIIIa) and factor VII gene polymorph isms on the risk of thrombosis in thalassemic patients. A higher prevalence of the FVII H7 allele in subjects without thrombosis suggests that this ge netic marker confers protection against thrombosis.