The effect of cisapride on gallbladder contractility in type II diabetic patients

Background/Aims: To investigate whether diabetics have altered gallbladder motility, and whether cisapride has any effect on gallbladder motility in t hese patients. The factors associated with abnormal gallbladder contractili ty, and with the effects of cisapride on gallbladder contractility in diabe tics were also evaluated. Methodology: The gallbladder contractility parameters of 20 diabetics and 2 0 controls were assessed by real time ultrasonography. The same measurement s were made after cisapride treatment in diabetics. Results: Fasting gallbladder volume and residual gallbladder volume were st atistically higher in the diabetic group than in the controls (P = 0.018 an d P = 0.022, respectively). Multivariate analysis also showed a significant association between fasting gallbladder volume and existing diabetes (P = 0.0002). There was a significant positive correlation between level of hemo globin Ale and fasting gallbladder volume (r = 0.48, P = 0.031). Responders to cisapride treatment had significantly higher hemoglobin Ale levels than nonresponders (6.6 +/- 1.3 vs. 9.1 +/- 1.8, respectively; P = 0.004). Logi stic multiple regression analysis revealed that hemoglobin Ale level was th e only independent factor that was predictive for efficacy of cisapride tre atment. Conclusions: This study demonstrates that diabetics have impaired gallbladd er contractility, and that control of diabetes is predictive for gallbladde r contractility and response to cisapride therapy in these patients.