Polymer-assisted solution-phase organic synthesis: Advances in multi-step synthetic applications

Polymer-assisted solution-phase synthesis has emerged as a versatile approa ch for high throughput generation of focused chemical libraries. The strate gy provides an integrated solution for chemical synthesis and purification by assimilating the advantages of product isolation and purification of sol id-phase organic synthesis with the flexible choice of solution-phase chemi stry. The ongoing surge in the generation of small molecule libraries by pa rallel synthesis has spawned keen interest in the development of novel immo bilized reagents, catalysts and scavengers. This short review will focus on ly on the advances of this technology in multi-step organic synthesis.