Naturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against alpha-toxin-associated diseases

Authors
Schoepe, H Pache, C Neubauer, A Potschka, H Schlapp, T Wieler, LH Baljer, G
Citation
H. Schoepe et al., Naturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against alpha-toxin-associated diseases, INFEC IMMUN, 69(11), 2001, pp. 7194-7196
Citations number
16
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
11
Year of publication
2001
Pages
7194 - 7196
Database
ISI
SICI code
0019-9567(200111)69:11<7194:NOCPNA>2.0.ZU;2-K
Abstract
Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phos pholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the cor responding alpha-toxin variant are detectable. Vaccination with this geneti cally constructed alpha-toxin variant, rAT121/91, induces antibodies capabl e of significantly reducing activities induced by wild-type toxin. Thus, rA T121/91 could be a useful vaccine candidate.