Increasing relevance of pharmacogenetics of drug metabolism in clinical practice

Authors
Citation
Pi. Pillans, Increasing relevance of pharmacogenetics of drug metabolism in clinical practice, INTERN M J, 31(8), 2001, pp. 476-478
Citations number
16
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
INTERNAL MEDICINE JOURNAL
ISSN journal
14440903 → ACNP
Volume
31
Issue
8
Year of publication
2001
Pages
476 - 478
Database
ISI
SICI code
1444-0903(2001)31:8<476:IROPOD>2.0.ZU;2-5
Abstract
Much of the individual variation in drug response is due to genetic drug me tabolic polymorphisms. Clinically relevant examples include acetylator stat us; cytochrome P450 2D6, 2C9 and 2C19 polymorphisms; and thiopurine methylt ransferase deficiency. It is important to be aware of which drugs are subje ct to pharmacogenetic variability. In the future, population-based pharmaco genetic testing will allow more individualized drug treatment and will avoi d the current empiricism.