"Hit-and-run" actions at dopamine receptors, part 1 mechanism of action ofatypical antipsychotics

Authors
Stahl, SM
Citation
Sm. Stahl, "Hit-and-run" actions at dopamine receptors, part 1 mechanism of action ofatypical antipsychotics, J CLIN PSY, 62(9), 2001, pp. 670-671
Citations number
8
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
JOURNAL OF CLINICAL PSYCHIATRY
ISSN journal
01606689 → ACNP
Volume
62
Issue
9
Year of publication
2001
Pages
670 - 671
Database
ISI
SICI code
0160-6689(200109)62:9<670:"AADRP>2.0.ZU;2-Q
Abstract
Hypothetically, if an antipsychotic blocks a dopamine-2 receptor and then r apidly dissociates from it (i.e., "hit-and-run" action), it has atypical an tipsychotic properties, namely reduction of psychosis without production of motor side effects.