Dendritic cell-based therapy: A review focusing on antigenic selection

Recently, technologies have developed that allow for the culturing of antig en-presenting cells (APC), such as dendritic cells (DC). The normal functio n of these cells is to present antigens to T cells, which then specifically recognize and ultimately eliminate the antigen source. Over the past numbe r of years, these cells have been used in a variety of different immunother apeutic strategies. Paramount in the success of such endeavors is the gener ation of desired T cell responses through the selection of appropriate anti gens. This paper will serve to discuss the development and current status o f dendritic cell-based therapy focusing on antigen selection for cancer.