Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical preparations

Authors
Perez-Ruiz, T Martinez-Lozano, C Tomas, V Sanz, A Sahuquillo, E
Citation
T. Perez-ruiz et al., Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical preparations, J PHARM B, 26(4), 2001, pp. 609-615
Citations number
37
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
26
Issue
4
Year of publication
2001
Pages
609 - 615
Database
ISI
SICI code
0731-7085(200111)26:4<609:FEMFTD>2.0.ZU;2-F
Abstract
The spectrophotometric determination of trace amounts of ranitidine was car ried out by liquid-liquid extraction using bromothymol blue with a flow sys tem. The determination of ranitidine in the range of 1 x 10(-5)-1 x 10(-4) mol l(-1) was possible with a sampling frequency of 40 samples h(-1), The m ethod was satisfactorily applied to the determination of ranitidine in phar maceutical preparations and the recovery was quantitative and no interferen ces from excipients were observed. (C) 2001 Elsevier Science B.V. All right s reserved.