Brooke-Spiegler syndrome

The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a giv en family, some members may have cylindromas whereas others may have tricho epitheliomas or both. We describe the coexistence of trichoepithelioma papu losum multiplex (also known as epithelioma adenoides cysticum of Brooke) an d cylindromas in a 30-year-old man, and discuss the relationship between th ese two autosomal dominant syndromes.