Metastasis to the penis in a patient with squamous cell carcinoma of the lung with a review of reported cases

Metastasis to the penis is very rare in lung cancer. We describe a patient with squamous cell carcinoma of the lung who developed a metastatic lesion in the penis. A 75-year-old Japanese male visited a local hospital complain ing cough and bloody sputum. A chest plain radiograph and computed tomograp hic (CT) scans of the chest demonstrated a right hilar mass. He was diagnos ed with squamous cell carcinoma of the lung at stage IIIB (T4N2M0). Then he was treated with concurrent chemoradiotherapy consisting of cisplatin, doc etaxel, and thoracic irradiation, and after the chemo radiotherapy, he achi eved a partial response. However, 6 months later, he visited an urologist c omplaining of firm mass in the penis with slight pain. A biopsy of the corp us cavernosum penis was performed, which provided a histological diagnosis of squamous cell carcinoma. The histology of the specimen was consistent wi th that of previous lung cancer, so he was considered to have penile metast asis from squamous cell carcinoma of the lung. Radiotherapy was given to th e metastatic tumor in the penis. The penile tumor was diminished and the pa in was completely relieved. In addition, we review reported cases to invest igate the clinical characteristics and appropriate management of this rare involvement. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.