Autoimmune disease: why and where it occurs

Authors
Marrack, P Kappler, J Kotzin, BL
Citation
P. Marrack et al., Autoimmune disease: why and where it occurs, NAT MED, 7(8), 2001, pp. 899-905
Citations number
99
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
7
Issue
8
Year of publication
2001
Pages
899 - 905
Database
ISI
SICI code
1078-8956(200108)7:8<899:ADWAWI>2.0.ZU;2-2
Abstract
Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overal l reactivity of the immune system, the specific antigen and its presentatio n, and the target issue.