GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis

Authors
Wiendl, H Bien, CG Bernasconi, P Fleckenstein, B Elger, CE Dichgans, J Mantegazza, R Melms, A
Citation
H. Wiendl et al., GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis, NEUROLOGY, 57(8), 2001, pp. 1511-1514
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
8
Year of publication
2001
Pages
1511 - 1514
Database
ISI
SICI code
0028-3878(20011023)57:8<1511:GAPIFE>2.0.ZU;2-O
Abstract
Eight patients with Rasmussen's encephalitis, 40 patients with noninflammat ory focal epilepsy, 104 patients with various neurologic diseases, and 16 h ealthy donors were tested for the prevalence of antibodies against the GluR 3 receptor in serum and CSF. Reactivities against different peptides derive d from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in th ose with other neurologic diseases, but they were not specific for the diag nosis of Rasmussen's encephalitis.