IDIOPATHIC MYELOFIBROSIS WITH NEUTROPHIL MYELOPEROXIDASE DEFICIENCY -A CASE-REPORT

Authors
CAENAZZO A PIVA E SARTORI D STEFANI PM
Citation
A. Caenazzo et al., IDIOPATHIC MYELOFIBROSIS WITH NEUTROPHIL MYELOPEROXIDASE DEFICIENCY -A CASE-REPORT, Haematologica, 82(4), 1997, pp. 465-467
Citations number
10
Categorie Soggetti
Hematology
Journal title
Haematologica → ACNP
ISSN journal
03906078
Volume
82
Issue
4
Year of publication
1997
Pages
465 - 467
Database
ISI
SICI code
0390-6078(1997)82:4<465:IMWNMD>2.0.ZU;2-9
Abstract
We describe a case of idiopathic myelofibrosis with total neutrophil m yeloperoxidase deficiency. The combination of this enzymatic defect wi th myelofibrotic changes in the nuclear shape of neutrophils confers a peculiar appearance on leukograms produced by a Technicon H1. The cl inical course of the disease was shortened by recurrent infections tha t may be ascribed, at least in part, to reduced leukocyte microbicidal ability. (C) 1997, Ferrata Storti Formulation.