Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

Authors
Coates, PJ Lorimore, SA Rigat, BA Lane, DP Wright, EG
Citation
Pj. Coates et al., Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice, ONCOGENE, 20(48), 2001, pp. 7096-7097
Citations number
8
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ONCOGENE
ISSN journal
09509232 → ACNP
Volume
20
Issue
48
Year of publication
2001
Pages
7096 - 7097
Database
ISI
SICI code
0950-9232(20011025)20:48<7096:IOEBBI>2.0.ZU;2-B
Abstract
Studies of the response of p53-lacZ transgenic mice have uncovered an unexp ected induction of endogenous acid-beta -galactosidase activity following w hole body irradiation. Strong induction of endogenous enzyme activity is se en in a variety of mouse strains commonly used in the production of transge nes. The induction of endogenous enzyme activity therefore complicates the analysis of p53-lacZ transgenes and may also influence the analysis of radi ation responses in other lacZ-reporter mice.