The transmembrane adapter LAT plays a central role in immune receptor signalling

Citation
P. Wonerow et Sp. Watson, The transmembrane adapter LAT plays a central role in immune receptor signalling, ONCOGENE, 20(44), 2001, pp. 6273-6283
Citations number
99
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ONCOGENE
ISSN journal
09509232 → ACNP
Volume
20
Issue
44
Year of publication
2001
Pages
6273 - 6283
Database
ISI
SICI code
0950-9232(20011001)20:44<6273:TTALPA>2.0.ZU;2-5
Abstract
The transmembrane adapter LAT (linker for activation of T cells) plays a ce ntral role in signalling by ITAM bearing receptors expressed on T cells, na tural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of tyrosine residues present in the intracellular domai n of LAT and formation of a multiprotein complex with other adapter molecul es and enzymes including Grb2, Gads/SLP-76 and PLC gamma isoforms. These si gnalling events predominantly take place in glycolipid-enriched membrane do mains. The constitutive presence of LAT in GEMs enables its function as the main scaffolding protein for the organization of GEM-localized signalling. The study of LAT-deficient mice and LAT-deficient cell lines further empha sizes the importance of LAT for these signalling cascades but also defines the existence of LAT-independent events downstream of the Syk-family kinase -ITAM complex.