Evaluation of a single stage nitroglycerin tilt table test for diagnosis of neurally mediated syncope

Citation
Cy. Zeng et al., Evaluation of a single stage nitroglycerin tilt table test for diagnosis of neurally mediated syncope, PACE, 24(10), 2001, pp. 1494-1499
Citations number
16
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
ISSN journal
01478389 → ACNP
Volume
24
Issue
10
Year of publication
2001
Pages
1494 - 1499
Database
ISI
SICI code
0147-8389(200110)24:10<1494:EOASSN>2.0.ZU;2-D
Abstract
The purpose of this study was to compare clinical outcomes between a single stage head-up tilt table test (HUT) with infusion of 3.44 mug/kg per hour of nitroglycerin and a conventional multistage test with infusion of nitrog lycerin from 1.72 mug/kg per hour to 5.16 mug/kg per hour in five successiv e stages. Thirty-seven patients with recurrent syncope underwent both tests in a prospective, randomized, crossover fashion. During single stage HUT, a positive response occurred in 24 (64.9%) patients with unexplained syncop e, an exaggerated response occurred in 3 (8.1%), a negative response in 7 ( 18.9%), and drug intolerance in 3 (8.1%). During the multistage HUT, these percentages were 62.2%, 16.2%, 13.5%, and 8.1%, respectively. Twenty health y control subjects were involved in both tests. One of the control subjects had a positive response to single stage HUT, and two (10%) patients to mul tistage HUT. The duration of the test in single stage HUT was shorter than that in multistage HUT (8.6 +/- 10.3 vs 38.6 +/- 32.1 minutes, P < 0.01). T he results showed that the single stage HUT was a fairly sensitive, specifi c, and a time-efficient test for provoking neurally mediated syncope.