How to prolong postoperative analgesia after caudal anaesthesia with ropivacaine in children: S-ketamine versus clonidine

Background: The aim of the study was to determine whether caudal S-ketamine or clonidine prolonged analgesia together with ropivacaine. Methods: Sixty-three boys, aged 1-5 years, who were undergoing minor surger y, were allocated in order to receive one of three solutions for caudal ana esthesia. Group R received 2 mg.kg(-1) 0.2% ropivacaine; group C, 2 mg.kg(- 1) 0.2% ropivacaine + clonidine 2 mug.kg(-1); and group K, 2 mg.kg(-1) 0.2% ropivacaine + S-ketamine 0.5 mg.kg(-1). Results: Postoperative analgesia assessed by CHEOPS lasted 701 min in group K (P < 0.05) compared with 492 min in group C and 291 min in group R. Ther e were no significant differences between the groups for incidence of haemo dynamic and respiratory alterations, motor block or sedation. Conclusions: This study demonstrates that S-ketamine 0.5 mg.kg(-1) when add ed to 0.2% caudal ropivacaine provides better postoperative analgesia than clonidine without any clinically significant side-effect.