M. Sklair-levy et al., Percutaneous image-guided needle biopsy in children - summary of our experience with 57 children, PEDIAT RAD, 31(10), 2001, pp. 732-736
Background. Percutaneous image-guided needle biopsy in children has been sl
ower to gain acceptance than in adults where it is regarded as the standard
clinical practice in screening suspicious masses.
Objectives. To report our experience with percutaneous image-guided needle
biopsy in the pediatric population and assess its clinical use, efficacy an
d limitations.
Material and methods. Sixty-nine percutaneous image-guided needle biopsies
were performed in 57 children. The age of the children ranged from 4 days t
o 14 years (mean 5.6 years). We used 16- to-20-gauge cutting-edge needles.
Sixty-two biopsies were core-needle biopsies and 7 fine-needle aspiration b
iopsies.
Results. There were 50 malignant lesions, 10 benign lesions and 2 infectiou
s lesions. In 55 (88.7%) lesions the needle biopsy was diagnostic. In 7 (11
.3%) the biopsy was non-diagnostic and the diagnosis was made by surgery. C
ore-needle biopsy was diagnostic in 47 of 50 (94%) of the malignant solid t
umors. In 3 out of 5 children with lymphoma, an accurate diagnosis was obta
ined with needle aspiration. Seven children underwent a repeated core-needl
e biopsy, (5 for Wilms' tumor and 2 for neuroblastoma) that was diagnostic
in all cases. All the biopsies were performed without complications.
Conclusion. Percutaneous image-guided needle biopsy is a simple, minimally
invasive, safe and accurate method for the evaluation of children with susp
icious masses. These data suggest that image-guided needle biopsy is an exc
ellent tool for diagnosing solid tumors in the pediatric population. Negati
ve studies should be considered nondiagnostic and followed by excisional su
rgical biopsies when clinical suspicion of malignancy is high.