The incidence of staphylococcal toxic shock syndrome (TSS) has decreased st
eadily since the 1980s, when it was first linked with use of superabsorbent
tampons by menstruating women. Nonetheless, the disorder still occurs and
sometimes is overlooked as a possible cause of acute illness. TSS now is re
cognized as a toxin-mediated, multisystem illness that strikes primarily in
healthy people of any age. It is characterized by early onset of shock wit
h multiorgan failure and continues to be associated with high morbidity and
mortality. In this article, Drs Issa and Thompson discuss clinical present
ation, pathogenesis, treatment, and outcome of staphylococcal TSS.