Coagulase-negative staphylococci are among the most commonly isolated bacte
ria in clinical microbiology laboratories. Such coagulase-negative, novobio
cin-susceptible staphylococci as Staphylococcus epidermidis have emerged as
a major cause of infection, particularly in hospitalized patients with ind
welling foreign bodies and in immunocompromised patients. In this article,
Drs von Eiff, Proctor, and Peters discuss the role of these pathogens in ba
cteremia, polymer-associated infection, endocarditis, and urinary tract inf
ection (UTI).