R. Goodwin et al., Obsessive-compulsive disorder and separation anxiety co-morbidity in earlyonset panic disorder, PSYCHOL MED, 31(7), 2001, pp. 1307-1310
Background. This study was undertaken to examine the relationship between a
nxiety co-morbidity and age of onset of panic disorder.
Methods. Age of onset of panic disorder and co-morbid anxiety disorders wer
e assessed among 201 panic disorder probands with childhood separation anxi
ety disorder, obsessive-compulsive disorder, obsessive-compulsive symptoms,
social phobia and specific phobia as part of a clinician-administered life
time diagnostic interview. A generalized linear model was used to test the
association between each anxiety co-morbidity and age of panic disorder ons
et while simultaneously controlling for the potential confounding effects o
f sociodemographic characteristics and other psychiatric co-morbidity.
Results. Earlier onset of panic disorder was found in patients with co-morb
id obsessive-compulsive disorder, obsessive-compulsive symptoms and separat
ion anxiety disorder, but not simple phobia or social phobia. Patients with
both childhood separation anxiety disorder and obsessive-compulsive disord
er had an even earlier panic onset than those with either childhood separat
ion anxiety disorder or obsessive-compulsive disorder.
Conclusions. The association between anxiety co-morbidity and earlier onset
of panic disorder is specific to obsessive-compulsive disorder and childho
od separation anxiety disorder.