Diagnosis criteria of multiple sclerosis in neuroimaging

To date, there is no biological test available with enough confidence to ma ke alone a diagnosis of Multiple Sclerosis (MS). MS diagnosis criteria are then an association of clinical and para clinical criteria that allow an ob jective demonstration of dissemination of lesions in both time and space. A dapted MRI criteria from Barkhof have a good sensitivity and the best speci ficity to evaluate MS. 3 of 4 criteria are necessary: 1 gadolinium enhancin g lesion or 9 T2 hyper intense lesions; at least 1 infratentorial lesion; a t least 1 juxtacortical lesion; at least four periventricular lesions, NB: 1 spinal cord lesion can substitute for I brain lesion. News methods as spe ctroscopy, magnetization transfer, diffusion MRI and functional MRI complet e results of conventional MRI and give new informations about physiopatholo gy of MS demyelinating lesions.