Biologic diagnostic criteria of multiple sclerosis

The clinical diagnosis of multiple sclerosis (MS) can be supported by the a nalysis of the cerebrospinal fluid (CSF) by the detection of an inflammator y reaction in central nervous system. The most sensitive method for the det ection of oligoclonal IgG bands is isoelectric focusing. However magnetic r esonance imaging (MRI) is more sensitive and predictive. Nevertheless CSF s tudy is useful in monosymptomatic manifestation when MRI is normal, and pri mordial in primary progressive MS diagnosis. More studies are needed to det ermine the optimal sequence of CSF study, MRI and evoked potentials in the diagnosis of different presentation of MS.