Diagnosis criteria of multiple sclerosis (MS) have been recently reconsider
ed, introducing the possibility to validate temporal dissemination with the
use of MRI. In fact, MRI parameters may be considered as reflecting the bi
ological activity of MS. MRI is used to monitor treatment in clinical trial
s. However, and except for particular circumstances, its use in routine fol
low-up of patients with MS is not recommended, because of weak correlations
with clinical disability and technical difficulties of such follow-up.