Differential-diagnostic and prognostic value of serum cytokines sCD30, sIL2R, IL-10 and IL-6 in Hodgkin's disease and non-Hodgkin's lymphomas

Aim. Determination of the importance of serum cytokines (sCD30, sIL-2R, IL- 10, IL-6) for diagnosis, response to chemotherapy and remission in patients with lymphogranulomatosis and lymphosarcoma. Material and methods. Cytokine concentrations were measured in 87 samples o f serum (plasma) from 54 patients by ELISA. Diagnosis of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) was made histologically in 24 and 30 patients, respectively. Results. The threshold concentrations of sCD30 (and less specific sIL-2R) f or HD and NHL patients allowed to estimate sensitivity to chemotherapy afte r the second course. The threshold concentration of IL-10 can distinguish H D fi-om NHL. Changes in IL-6 concentrations were nonspecific. Conclusion. On the basis of the threshold concentrations of sCD30 and IL-10 we offer the scheme of lymphoma diagnosis and prediction of the disease se nsitivity to chemotherapy which reduce the duration of lymphoma restaging.