A facile method for deprotection of trityl ethers using column chromatography

Authors
Pathak, AK Pathak, V Seitz, LE Tiwari, KN Akhtar, MS Reynolds, RC
Citation
Ak. Pathak et al., A facile method for deprotection of trityl ethers using column chromatography, TETRAHEDR L, 42(44), 2001, pp. 7755-7757
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
44
Year of publication
2001
Pages
7755 - 7757
Database
ISI
SICI code
0040-4039(20011029)42:44<7755:AFMFDO>2.0.ZU;2-5
Abstract
A mild, efficient and inexpensive detritylation method is reported that use s trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds with only slight alterations in the procedure. Nin eteen examples are given. (C) 2001 Elsevier Science Ltd. All rights reserve d.