Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel

Authors
Nakai, K Kamoshita, M Doi, T Yamada, H Takahashi, T
Citation
K. Nakai et al., Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel, TETRAHEDR L, 42(44), 2001, pp. 7855-7857
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
44
Year of publication
2001
Pages
7855 - 7857
Database
ISI
SICI code
0040-4039(20011029)42:44<7855:SARTRC>2.0.ZU;2-D
Abstract
We have developed a practical synthetic route for the A and C rings of pacl itaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyal kene. (C) 2001 Elsevier Science Ltd. All rights reserved.