K. Nakai et al., Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel, TETRAHEDR L, 42(44), 2001, pp. 7855-7857
We have developed a practical synthetic route for the A and C rings of pacl
itaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyal
kene. (C) 2001 Elsevier Science Ltd. All rights reserved.