LFA-1 and ICAM-1 antibody-idarubicin conjugates separately prolong murine cardiac allograft survival

Drug antibody conjugates can enhance the activity of monoclonal antibodies (MoAb) and idarubicin-MoAb conjugates have led to tolerance induction with antibodies which are inactive when used alone. It has been reported that, i n mice, antibodies to ICAM-1 and LFA-1 have to be used together to induce t olerance to cardiac allografts; here we show that these monoclonal antibodi es, conjugated to idarubicin, can lead to tolerance induction to cardiac al lografts when used alone. (C) 2001 Elsevier Science B.V. All rights reserve d.