Kidney preservation with university of Wisconsin and Celsior solution: A prospective multicenter randomized study

Background. Although the University of Wisconsin (U.W.) solution continues to be the most commonly used for intra-abdominal organs, a new solution, Ce lsior, already used for heart and lungs, has been proposed for kidney and l iver preservation. The aim of this research was to assess the effect of Cel sior as compared with U.W. on immediate graft function and a 2-year follow- up of kidney transplants. Methods. A prospective multicenter randomized study was designed to evaluat e the efficacy of the Celsior solution in the clinical preservation of the kidney. In this report, we present the data collected as of September 2000. One hundred donors were included in the trial resulting in 187 renal trans plants. Ninety-nine kidneys were stored in Celsior solution and 88 in U.W. solution. The groups were comparable with regard to donor and recipient cha racteristics. Results. Delayed graft function occurred in 31.3% of the Celsior group and in 33.9% of the U.W. group (P=n.s.). Mean serum creatinine levels and mean daily urinary output were also comparable. Two year graft survival in kidne ys preserved with Celsior was 84% as compared with 75% for U.W.-preserved k idneys without any significant statistical difference. Conclusions. Our data show that the preservation of kidneys in Celsior solu tion in a clinical setting is equivalent to that of U.W. solution. When usi ng Celsior during multiple-organ donor harvesting it would be possible to p erform an in situ Rush of all intra-abdominal and intrathoracie organs with a single cold storage solution.