Early prenatal sonographic diagnosis and follow-up of Jeune syndrome

Jeune syndrome or asphyxiating thoracic dysplasia is an autosomal recessive osteochondrodysplasia. It is one of the six short-rib (polydactyly) syndro mes. The disease has a wide spectrum of manifestations, ranging from a late nt to a mild or lethal condition. We describe the prenatal sonographic diag nosis of Jeune syndrome at 14 weeks of gestation in a fetus at risk for thi s condition, and the development of the syndrome throughout the pregnancy.