Quartz crystal resonant sensor (QCRS) model for label-free, small molecules - receptor studies

Studying the binding mechanisms of potential drug candidates to receptors o f interest is of huge importance to the pharmaceutical industry and laborat ory workers worldwide. Reliable arrangements for following interactions bet ween low molecular weight samples and their potential receptors without the requirement for labelling are uncommon. Quartz crystal resonant sensors (Q CRS) are becoming established as label-free tools for observing the interac tions between species in liquid media. Here we describe a new model based u pon QCRS technology and novel thiol surface chemistry, capable of detecting the interactions between low molecular weight sugars and their host recept ors in real-time.