The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: Synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities

Authors
Doss, SH Wardakhan, WW Louca, NA
Citation
Sh. Doss et al., The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: Synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities, ARCH PH RES, 24(5), 2001, pp. 377-384
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
24
Issue
5
Year of publication
2001
Pages
377 - 384
Database
ISI
SICI code
0253-6269(200110)24:5<377:TRODAD>2.0.ZU;2-K
Abstract
The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of t he latter products towards chemical reagents was studied to give heterocycl ic derivatives with potential biological activities.