Ew. Son et al., Inhibition of gamma-irradiation induced adhesion molecules and NO production by alginate in human endothelial cells, ARCH PH RES, 24(5), 2001, pp. 466-471
Inflammation is a frequent radiation-induced reaction following therapeutic
irradiation. Treatment of human umbilical endothelial cells (HUVEC) with g
amma -irradiation (gamma IR) induces the expression of adhesion proteins su
ch as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion mo
lecule-1 (VCAM-1), and E-selectin. Since the upregulation of these proteins
on endothelial cell surface has been known to be associated with inflammat
ion, interfering with the expression of adhesion molecules is an important
therapeutic target. in the present study, we demonstrate that high mannuron
ic acid-containing alginate (HMA) inhibits gamma IR induced expression of I
CAM-1, VCAM-1, and E-selectin on HUVEC in a dose dependent manner. HMA also
inhibited gamma IR induced production of Nitric oxide (NO). These data sug
gest that HMA has therapeutic potential for the treatment of various inflam
matory disorder associated with an increase of endothelial leukocyte adhesi
on molecules.