An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application

Authors
Citation
Tv. Chirila, An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application, BIOMATERIAL, 22(24), 2001, pp. 3311-3317
Citations number
75
Categorie Soggetti
Multidisciplinary
Journal title
BIOMATERIALS
ISSN journal
01429612 → ACNP
Volume
22
Issue
24
Year of publication
2001
Pages
3311 - 3317
Database
ISI
SICI code
0142-9612(200112)22:24<3311:AOOTDO>2.0.ZU;2-H
Abstract
An overview of the efforts to develop functional polymeric artificial corne as (keratoprostheses) by incorporating a porous skirt is presented. The dev elopment of such a device by the author's group using poly(2-hydroxyethyl m ethacrylate) (PHEMA) hydrogels, as a combination of their homogeneous and h eterogeneous states, and the rationale of this choice are also discussed. T he latest results of the clinical trials with the PHEMA keratoprosthesis in human patients indicate a lower risk of the complications traditionally as sociated with the implantation of artificial corneas. (C) 2001 Elsevier Sci ence Ltd. All rights reserved.